The US Navy shot down 21 Houthi missiles and drones launched from Yemen, according to a statement from US Central Command, in one of the largest Houthi attacks to take place in the Red Sea in recent months.

The military called it a “complex attack” carried out by the Iranian-backed militants.

The barrage, launched at about 9:15 p.m. Tuesday in Yemen, included 18 one-way attack drones, two anti-ship cruise missiles and one anti-ship ballistic missile, Central Command said. The attack was launched toward international shipping lanes in the southern Red Sea where “dozens” of merchant vessels were traveling, according to the statement.

There were no ships damaged in the attacks and no injuries as a result of the massive drone and missile launch, CENTCOM said.

Three destroyers took part in the shoot down of the barrage, one of the officials said.

Two US destroyers, as well as F-18 fighter jets from the USS Dwight D. Eisenhower aircraft carrier, participated in the combined effort to shoot down the missiles and drones, according to Central Command. The HMS Diamond, an air defence destroyer from the UK’s Royal Navy, was also part of the effort.

The US and other nations have a number of ships in the Red Sea as part of Operation Prosperity Guardian, a multi-national effort to safeguard shipping in one of the world’s most critical waterways. The coalition consists of more than 20 countries.

The launch comes as US Secretary of State Antony Blinken is visiting the Middle East in an attempt to contain the Gaza war and prevent a regional escalation.

Blinken was in Israel on Tuesday, where he told officials that Palestinians in Gaza must be allowed to return to their homes “as soon as conditions allow.” The secretary has repeatedly called on the Israeli government to reduce the number of civilian casualties as a result of Israel’s bombardment of Gaza.

The Iran-backed Houthis have said their launches of drones and missiles are showing solidarity with the Palestinian people. Their first series of attacks, which began shortly after the start of the Israel-Hamas war, targeted commercial vessels with some connection to Israel. To date, the Houthis have carried out 26 attacks on commercial vessels in the Red Sea, according to Central Command.

But most of the last dozen attacks had no connection to Israel at all, Vice Adm. Brad Cooper, the commander of US Naval Central Command, said last week, even as it draws more nations into the situation.

The US assesses that 55 nations have direct connections to the ships that have been attacked, whether through the flagging state of the ship, the nationality of the crew, the ship’s origin and destination, or the vessels’ ownership.

“The impact of these attacks spreads across the globe, and as we’ve said, this is an international problem that requires an international solution,” Cooper said.

In a joint statement last week, the US and about a dozen other countries condemned the continuing Houthi attacks, warning, “The Houthis will bear the responsibility of the consequences should they continue to threaten lives, the global economy, and free flow of commerce in the region’s critical waterways.”

Central Command reiterated that threat in the statement about the latest attack.