Yemen’s Houthi rebels launched a missile Friday at a United States warship patrolling the Gulf of Aden, forcing it to shoot down the projectile, and struck a British vessel as their aggressive attacks on maritime traffic continue.

The attack on the U.S. warship, the destroyer USS Carney, marked a further escalation in the biggest confrontation at sea the U.S. Navy has seen in the Middle East in decades, as Houthi missile fire set another commercial vessel ablaze Friday night.

Early Saturday local time, U.S. forces conducted a strike against a Houthi anti-ship missile that was aimed into the Red Sea and prepared to launch, the U.S. military’s Central Command said.

The Houthis’ Al-Masirah satellite news channel said the strikes happened near the port city of Hodeida, but offered no assessment of their damage.